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Mechanism of action of non narcotic analgesics

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Opioids are substances that, when reaching opioid receptors , have effects similar to those of morphine. Side effects of opioids may include itchiness , sedation , nausea , respiratory depression , constipation , and euphoria. Long-term use can cause tolerance , meaning that increased doses are required to achieve the same effect, and physical dependence , meaning that abruptly discontinuing the drug leads to unpleasant withdrawal symptoms. An overdose or concurrent use with other depressant drugs like benzodiazepines or alcohol commonly results in death from respiratory depression.
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What Is an Analgesic?

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Analgesic - Side Effects & Precautions | Everyday Health

Medically reviewed by C. Fookes, BPharm. Last updated on April 12, Analgesics are medicines that are used to relieve pain. They are also known as painkillers or pain relievers.
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How Do Opioids Work? Mechanism of Action

Narcotic agents are potent analgesics which are effective for the relief of severe pain. Analgesics are selective central nervous system depressants used to relieve pain. The term analgesic means "without pain". Even in therapeutic doses, narcotic analgesics can cause respiratory depression, nausea, and drowsiness. Long term administration produces tolerance, psychic, and physical dependence called addiction.
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Though they're widely used as painkillers, long-term use of analgesics can be risky. The medicines are commonly used to treat pain due to arthritis, surgery, injury, toothache, headache, menstrual cramps , sore muscles , or other causes. Opioids reduce the pain signals sent by the nervous system and the brain's reaction to those pain signals. Your risk of experiencing side effects depends on the type of analgesic you take, and how long you take it.

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