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Periventricular leukomalacia diagnosed in adult

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Periventricular leukomalacia PVL , the principal form of brain injury in the premature infant, is characterized by overt focal necrotic lesions in periventricular white matter and less prominent, more diffuse cerebral white matter injury. The early detection of the latter, diffuse component of PVL is not consistently possible with conventional brain imaging techniques. We demonstrate the early detection of the diffuse component of PVL by diffusion-weighted magnetic resonance imaging DWI. In a premature infant with no definite cerebral abnormality detectable by cranial ultrasonography or conventional magnetic resonance imaging, DWI showed a striking bilateral decrease in water diffusion in cerebral white matter. The DWI abnormality ie, decreased apparent diffusion coefficient was similar to that observed with acute cerebral ischemic lesions in adults.
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Periventricular Leukomalacia Information Page

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The Radiology Assistant : Neonatal Brain US

Periventricular leukomalacia, or PVL, involves injury to the brain. The periventricular area contains important nerve fibers that carry messages from the brain to the muscles of the body. Although all babies can develop the disease, premature babies are at an increased risk. The more premature the baby, the greater the risk of PVL.
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Periventricular Leukomalacia, or PVL

Skip to content. Periventricular leukomalacia PVL is characterized by the death or damage and softening of the white matter, the inner part of the brain that transmits information between the nerve cells and the spinal cord, as well as from one part of the brain to another. Periventricular means around or near the ventricles , the spaces in the brain containing the cerebrospinal fluid. With PVL, the area of damaged brain tissue can affect the nerve cells that control motor movements. As the baby grows, the damaged nerve cells cause the muscles to become spastic, or tight, and resistant to movement.
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Jump to navigation. When a person suffers a periventricular leukomalacia injury, these functions are impaired. PVL is a strikingly common causal factor among children with Cerebral Palsy that leads to intellectual impairment and spasticity that require therapy and treatment.

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